Germline CTLA-4 deficiency causes severe autoimmune diseases characterized by dysregulation of Foxp3+ Tregs, hyper-activation of effector memory T cells, and variable forms autoimmune cytopenia including gradual loss of B cells.Cancer patients with severe immune-related adverse events (irAE) after receiving anti-CTLA-4/PD-1 combination immunotherap
The recent COVID-19 pandemic has underscored the vulnerability of global health systems.Emerging in November 2019 in Hubei, China, COVID-19 has had far-reaching consequences, affecting every corner of the globe.The impact has been particularly severe, causing widespread collapse of public health systems and contraction of the world economy.The impo
Looking at the degraded natural landscape, as it appears today crossing the South of Italy, and especially Calabria, it appears to pass through a palimpsest of traces that can only let us guess what artists DESKS of the expedition Saint-Non saw about two hundred and forty years ago.The chaotic urban system, fragmented cultivated land, infrastructur
Calcium (Ca2+) and reactive oxygen species (ROS) are versatile signaling molecules coordinating physiological and pathophysiological processes.While channels and pumps shuttle Ca2+ ions between extracellular space, cytosol and cellular compartments, short-lived and highly reactive ROS are constantly generated by various production sites within the
Abstract Hepatocellular carcinoma (HCC) is a type of malignant tumor with sixth highest incidence and causes the third most cancer-related deaths in the world, whose treatment is limited by the unclear molecular mechanism.Currently, the correlation between PSMC2 and HCC is still unclear.Herein, we found that the expression of PSMC2 in HCC tissues w